AZ6197|AZ 6197;AZ-6197

Cas No.:	2023003-94-1
Chemical Name:	(R)-3-Methyl-7-(5-methyl-2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-2-((6-methylpyridin-2-yl)methyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one
Synonyms:	AZ 6197;AZ-6197
SMILES:	C12=CC(C3C(C)=CN=C(NC4N(C)N=CC=4)N=3)=CN1C[C@H](C)N(CC1=NC(C)=CC=C1)C2=O
Formula:	C₂₄H₂₆N₈O
M.Wt:	442.527
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AZ6197 (AZ-6197) is a potent, selective, reversible inhibitor of ERK1/2 with IC50 of <0.3 nM (ERK2), inhibits pERK/pRSK with IC50 of 12/62 nM in A375 cells, respectively; demonstrates in vivo antitumor efficacy.

Cat. No.	Product name	Field of application
DC47035	Edaxeterkib	Edaxeterkib is a potent extracellular signal-regulated kinase (ERK) inhibitor for the research of cancer.
DC42122	Pamoic acid disodium	Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively. Pamoic acid disodium potently recruits β-arrestin2 to GPR35 and has an antinociceptive effect.
DC28723	ERK-IN-2	ERK-IN-2 is a potent, highly seletive and orally active ERK2 inhibitor probe with an IC50 value of 1.8 nM. ERK-IN-2 might lead to off-target toxicity and/or off-target activity at dose >10 μM.
DC10985	AZ6197	AZ6197 (AZ-6197) is a potent, selective, reversible inhibitor of ERK1/2 with IC50 of <0.3 nM (ERK2), inhibits pERK/pRSK with IC50 of 12/62 nM in A375 cells, respectively.