GAK inhibitor 12r|CAS 2241325-66-4|DC Chemicals

Cas No.:	2241325-66-4
Chemical Name:	4-(3-(cis-2,6-Dimethylmorpholino)isothiazolo[4,3-b]pyridin-6-yl)-2-methoxyaniline
SMILES:	NC1=CC=C(C2C=NC3=C(N4C[C@@H](C)O[C@@H](C)C4)SN=C3C=2)C=C1OC
Formula:	C₁₉H₂₂N₄O₂S
M.Wt:	370.471
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

GAK inhibitor 12r is a higghly potent, selective inhibitor of cyclin G-associated kinase (GAK) with Kd of 89 nM; targets only 8 other kinases with greater than 90% inhibition in a diverse panel of 468 kinases; demonstrates broad-spectrum antiviral activity with EC50 of 0.82 uM against DENV-2, also shows activity against dengue virus, including in human primary dendritic cells, and efficacy against the unrelated Ebola and chikungunya viruses.

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