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| Cas No.: | 133825-80-6 |
| Chemical Name: | 1-(2,6-diisopropylphenyl)-3-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea |
| Synonyms: | ATR101;Nevanimibe;PD-132301 |
| SMILES: | N(C1=C(C(C)C)C=CC=C1C(C)C)C(NCC(C1=CC=C(N(C)C)C=C1)1CCCC1)=O |
| Formula: | C27H39N3O |
| M.Wt: | 421.629 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM; induces H295R cell apoptosis, causes mitochondrial hyperpolarization, reactive oxygen release, and ATP depletion, caspase-3/7 activation, and membrane permeabilization; decreases the formation of cholesteryl esters and increases FC levels in H295R adrenocortical carcinoma cells; inhibits the establishment and impeds the growth of ACC-derived H295R cell xenografts in mice; orally active. |