PC786|PC 786;PC-786

Cas No.:	1902114-15-1
Chemical Name:	N-(2-fluoro-6-methylphenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide
Synonyms:	PC 786;PC-786
SMILES:	N(C(=O)C1=CC=C(NC(=O)C2=C(N3CC4(CCOCC4)C3)N=CC(C)=C2)C=C1)1CCC2C=C(C(NC3=C(C)C=CC=C3F)=O)SC=2C2=CC=CC=C12
Formula:	C₄₁H₃₈FN₅O₄S
M.Wt:	715.844
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

PC786 (PC-786) is a potent non-nucleoside RSV L-protein polymerase inhibitor with IC50 of 2.1 nM and 0.5 nM in cell-free enzyme assay and mini-genome assay in HEp-2 cells, respectively; demonstrates a potent and selective anti-viral activity against laboratory adapted or clinical isolates of RSVA (IC50=<0.09-0.71 nM) and RSVB (IC50=1.3-50.6 nM) without causing detectable cytotoxicity.

Cat. No.	Product name	Field of application
DC10006	RSV-604	RSV604 is a novel inhibitor of respiratory syncytial virus replication(EC50=0.86 uM); a putative RSV nucleoprotein(N) inhibitor in phase 2 clinical trials.
DC11770	PC786	PC786 (PC-786) is a potent non-nucleoside RSV L-protein polymerase inhibitor with IC50 of 2.1 nM and 0.5 nM in cell-free enzyme assay and mini-genome assay in HEp-2 cells, respectively.