BI 135585|BI-135585;BI135585

Cas No.:	1114561-85-1
Chemical Name:	BI-135585
Synonyms:	BI-135585;BI135585
SMILES:	O1[C@](CC(O)(C)C)(C2=CC=CC=C2)CCN([C@@H](C2=CC=C(C3C=CN(C)C(=O)C=3)C=C2)C)C1=O
Formula:	C₂₈H₃₂N₂O₄
M.Wt:	460.574
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

BI 135585 (BI-135585, BI135585) is a potent, selective, orally active 11β-HSD1 inhibitor with IC50 of 4.3 nM and 53 nM in human adipocytes and primary human adipose tissue, respectively; exhibits >1,000-fold selectivity over other hydroxysteroid dehydrogenases; inhibits 11β HSD1 activity in adipose tissue, displays desirable pharmacodynamic properties in vivo.

Cat. No.	Product name	Field of application
DC11761	BMS-816336	A novel potent, selective, orally active human 11β-HSD1 inhibitor with IC50 of 3.0 nM.
DC11842	BI 135585	BI 135585 (BI-135585, BI135585) is a potent, selective, orally active 11β-HSD1 inhibitor with IC50 of 4.3 nM and 53 nM in human adipocytes and primary human adipose tissue, respectively.