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| Cas No.: | 1227067-61-9 |
| Chemical Name: | 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone |
| Synonyms: | AMG 579;AMG579 |
| SMILES: | C(=O)(N1CCC(C2=NC=CN=C2OC2=CC=C(C(C3=NC4=CC=CC=C4N3)=O)C=C2)CC1)C |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | AMG-579 is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM; displays high selectivity with IC50 > 30 uM against all other PDE isoforms; demonstrates excellent target occupancy efficacy in PCP-LMA behavioral model. |