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| Cas No.: | 479-50-5 |
| Chemical Name: | Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-4-methyl- (6CI,8CI) |
| SMILES: | C(=O)1C2=C(C=CC=C2)SC2=C1C(NCCN(CC)CC)=CC=C2C |
| Formula: | C20H24N2Os |
| M.Wt: | 340.482363700867 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | An orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APE1) potential antineoplastic activity, also inhibits autophagy; induces lysosomal membrane permeabilization, and possesses significantly more potent activity in breast cancer models compared with chloroquine; induces cathepsin D-mediated apoptosis. |