TC-2153|TC2153|CAS 1381769-23-8

Cas No.:	1381769-23-8
Chemical Name:	8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride
Synonyms:	TC2153
SMILES:	NC1=C2SSSSSC2=CC(C(F)(F)F)=C1.[H]Cl
Formula:	C₇H₅ClF₃NS₅
M.Wt:	355.869
Sotrage:	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

Description:

TC-2153 is a specific, small moelcule inhibitor of neuron-specific tyrosine phosphatase STEP with IC50 of 24.6 nM; increases tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2, and GluN2B, and exhibits no toxicity in cortical cultures, shows specificity towards STEP compared to several other tyrosine phosphatases; improves cognitive deficits in 3xTg-AD mice, with no change in beta amyloid and phospho-tau levels.

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