VT-1161|VT1161

Cas No.:	1340593-59-0
Chemical Name:	Oteseconazole
Synonyms:	Oteseconazole;VHH774W97N;BDBM50046187;DB13055;SB17420;2-Pyridineethanol, alpha-(2,4-difluorophenyl)-beta,beta-difluoro-alpha-(1H-tetrazol-1-ylmethyl)-5-(4-(2,2,2-trifluoroethoxy)phenyl)-, (alphaR)-;(2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-{5-[4-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-yl}propan-2-ol;C. albicans;T. rubrum
SMILES:	FC(C1C=CC(C2C=CC(=CC=2)OCC(F)(F)F)=CN=1)([C@@](C1C=CC(=CC=1F)F)(CN1C=NN=N1)O)F
Formula:	C₂₃H₁₆F₇N₅O₂
M.Wt:	527.39
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

VT-1161 is a potent, highly-selective, and oral fungal CYP51 inhibitor with Kd of ≤ 39 nM; demonstrates >2,000-fold selectivit over human CYP51, weakly inhibits human CYP2C9, CYP2C19, and CYP3A4; exhibits excellent potency against key yeast and dermatophyte strains.Fungal InfectionPhase 2 Clinical

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