MK-4618| CAS 1190389-15-1

Cas No.:	1190389-15-1
Chemical Name:	Vibegron
Synonyms:	VIBEGRON;M5TSE03W5U;C26H28N4O3;Vibegron [USAN:INN];vibegronum;Beova;Beova (TN);MK 4618;Vibegron (JAN/USAN);GTPL10100;BDBM50146154;MK4618;compound 7 [PMID: 26709102];SB16922;Pyrrolo(1,2-a)pyrimidine-6-carboxamide, 4,6,7,8-tetrahydro-N-(4-(((2S,5R)-5-((R)-hydroxyphenylmethyl)-2-pyrrolidinyl)methyl)phenyl)-4-oxo-, (6S)-;(6S)-N-(4-(((2S,5R)-5-((R)-Hydroxyphenylmethyl)pyrrolidin-2-yl)methyl)phenyl)-4
SMILES:	O([H])[C@]([H])(C1C([H])=C([H])C([H])=C([H])C=1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2C([H])=C([H])C(=C([H])C=2[H])N([H])C([C@]2([H])C([H])([H])C([H])([H])C3=NC([H])=C([H])C(N23)=O)=O)N1[H]
Formula:	C₂₆H₂₈N₄O₃
M.Wt:	444.5255
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent and selective full β3 adrenergic receptor agonist with EC50 of 1.1 nM; displays no activity for β1 and β2 receptors (EC50>20 uM); dose-dependently increases bladder capacity, decreased micturition pressure, and increased bladder compliance in rhesus monkeys, dose-dependently increases the circulating glycerol and fatty acid levels in rhesus and rat in vivo; shows the potential for treatment of overactive bladder with M2/M3 antimuscarinics.Other IndicationPhase 3 Clinical

Cat. No.	Product name	Field of application
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