VT-1598| CAS 2089320-99-8

Cas No.:	2089320-99-8
Chemical Name:	4-((4-(2-(6-((2R)-2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)-3-pyridinyl)ethynyl)phenoxy)methyl)benzonitrile
Synonyms:	AV9K9X720D;4-((4-((6-(2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)-3-pyridinyl)ethynyl)phenoxy)methyl)benzonitrile;4-((4-(2-(6-((2R)-2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)-3-pyridinyl)ethynyl)phenoxy)methyl)benzonitrile;Benzonitrile, 4-((4-(2-(6-((2R)-2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)-3-pyridinyl)ethynyl)phenoxy)methyl)-;Benzon
SMILES:	FC(C1C([H])=C([H])C(C#CC2C([H])=C([H])C(=C([H])C=2[H])OC([H])([H])C2C([H])=C([H])C(C#N)=C([H])C=2[H])=C([H])N=1)([C@@](C1C([H])=C([H])C(=C([H])C=1F)F)(C([H])([H])N1C([H])=NN=N1)O[H])F
Formula:	C₃₁H₂₀F₄N₆O₂
M.Wt:	584.5231
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

VT-1598 is a potent, high-affinity, oral inhibitor of fungal sterol 14α-demethylase (CYP51B) with Kd of 13 nM; is more selective for fungal CYP51 than related human CYP enzymes such as CYP3A4; exhibits excellent potency against yeast, dermatophyte, and mold fungal pathogens.

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