BMS-932481 |CAS 1263871-36-8|DC Chemicals

Cas No.:	1263871-36-8
Chemical Name:	5H-Cyclopenta(d)pyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-(3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-N4-methyl-, (7S)-
Synonyms:	9W144SV55B;(S)-7-(4-fluorophenyl)-N2-(3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-N4-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine;BDBM50458163;5H-Cyclopenta(d)pyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-(3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-N4-methyl-, (7S)-
SMILES:	FC1C=CC(=CC=1)[C@H]1C2C(=C(NC)N=C(NC3C=CC(=C(C=3)OC)N3C=NC(C)=N3)N=2)CC1
Formula:	C₂₄H₂₄FN₇O
M.Wt:	445.492067337036
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

BMS-932481 (BMS932481) is a potent, selective, orraly active γ-secretase modulator (GSM), shows selectivity for Aβ40 and Aβ42 reduction (IC50=6.6 nM) while sparing total Aβ levels both in vitro and in vivo; showed robust reductions of Aβ1–42 and Aβ1–40 in the plasma, brain, and cerebrospinal fluid of mice and rats. Consistent with the γ-secretase modulator mechanism, increases in Aβ1–37 and Aβ1–38 were observed, with no change in the total amount of Aβ1–x produced.

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BMS-932481(BMS932481;BMS 932481)