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ALC-0366

  Cat. No.:  DC60478   Featured
Chemical Structure
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More than 5000 active chemicals with high quality for research!
Field of application
ALC 0366 is an ionizable cationic lipid (pKa = 6.25) from Biontech,which is derived from ALC-0315. ALC0366 has been used as a key component of LNP to deliver BNT142, a lipid nanoparticle (LNP)-formulated RNA (RNA-LNP) encoding a T cell-engaging bispecific antibody that monovalently binds the T cell marker CD3 and bivalently binds claudin 6 (CLDN6), an oncofetal antigen that is absent from normal adult tissue but expressed on various solid tumors.
Chemicals PropertiesBiological activity Related products COA MSDS Datasheet
Cas No.:
Chemical Name: ALC-0366
Synonyms: ALC0366, ALC 0366,ALC366, ALC 366, ALC-366
SMILES: OCCCN(CCCCCCCCCOC(C(CCCC)CCCCCC)=O)CCCCCCCCCOC(C(CCCC)CCCCCC)=O
Formula: C45H89NO5
M.Wt: 724.2
Purity: ELSD-HPLC>95%
Sotrage: 1 year -20°C
Publication: Preclinical efficacy and pharmacokinetics of an RNA-encoded T cell-engaging bispecific antibody targeting human claudin 6-Sci Transl Med . 2024 May 22;16(748):eadl2720. doi: 10.1126/scitranslmed.adl2720.
Cat. No. Product name Field of application
DC60478 ALC-0366 ALC 0366 is an ionizable cationic lipid (pKa = 6.25) from Biontech,which is derived from ALC-0315. ALC0366 has been used as a key component of LNP to deliver BNT142, a lipid nanoparticle (LNP)-formulated RNA (RNA-LNP) encoding a T cell-engaging bispecific antibody that monovalently binds the T cell marker CD3 and bivalently binds claudin 6 (CLDN6), an oncofetal antigen that is absent from normal adult tissue but expressed on various solid tumors.
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