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Home > RNA Delivery > Cationic/Ionizable Lipids

11-10-8

  Cat. No.:  DC60825   Featured
Chemical Structure
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Field of application
11-10-8 is an ionizable cationic lipid (pKa = 6.22) that has been used in the generation of lipid nanoparticles (LNPs) for mRNA delivery in vivo.1 LNPs containing 11-10-8 and encapsulating mRNA encoding the Cas9 nuclease and small-guide RNA (sgRNA) targeting transthyretin (TTR), a thyroid hormone carrier protein, decrease serum levels of TTR in mice. LNPs containing 11-10-8 and encapsulating mRNA encoding human fibroblast growth factor 21 (hFGF21) increase serum levels of hFGF21, decrease body and liver weights, and reduce the liver steatosis score in a mouse model of obesity induced by a high-fat diet.
Chemicals PropertiesBiological activity Related products COA MSDS Datasheet
Cas No.:
Chemical Name: 11-10-8
Synonyms: ((2-(pyrrolidin-1-yl)ethyl)azanediyl)bis(decane-1,2-diyl) dioctanoate
SMILES: O=C(CCCCCCC)OC(CCCCCCCC)CN(CCN1CCCC1)CC(CCCCCCCC)OC(CCCCCCC)=O
Formula: C42H82N2O4
M.Wt: 679.1
Purity: >95%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Cat. No. Product name Field of application
DC60825 11-10-8 11-10-8 is an ionizable cationic lipid (pKa = 6.22) that has been used in the generation of lipid nanoparticles (LNPs) for mRNA delivery in vivo.1 LNPs containing 11-10-8 and encapsulating mRNA encoding the Cas9 nuclease and small-guide RNA (sgRNA) targeting transthyretin (TTR), a thyroid hormone carrier protein, decrease serum levels of TTR in mice. LNPs containing 11-10-8 and encapsulating mRNA encoding human fibroblast growth factor 21 (hFGF21) increase serum levels of hFGF21, decrease body and liver weights, and reduce the liver steatosis score in a mouse model of obesity induced by a high-fat diet.
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