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Home > Molecular Glues

VNPP433-3β

  Cat. No.:  DC67337   Featured
Chemical Structure
1630820-51-7
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Field of application
VNPP433-3β is a first-in-class molecular glue degrader that simultaneously targets ​androgen receptor (AR), its splice variants (AR-Vs), and Mnk1/2 kinases for proteasomal degradation. This multimodal agent demonstrates potent anti-proliferative activity in ​castration-resistant prostate cancer (CRPC) models, with ​GI50 values of 0.2–0.31 μM in LNCaP, C4-2B, and CWR22Rv1 cells. Its robust in vivo efficacy, evidenced by ​tumor growth inhibition in CWR22Rv1 xenografts, is supported by favorable pharmacokinetics in CD-1 mice.
Chemicals PropertiesBiological activity Related products COA MSDS Datasheet
Cas No.: 1630820-51-7
Chemical Name: VNPP433-3β
Synonyms: Galeterone 3β-imidazole
SMILES: C[C@@]12[C@](CC=C2N3C4=CC=CC=C4N=C3)([H])[C@@]5([H])[C@]([C@@]6(C(C[C@@H](N7C=CN=C7)CC6)=CC5)C)([H])CC1
Formula: C29H34N4
M.Wt: 438.61
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
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Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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