L52715| ionizable lipid|DC Chemicals

Cas No.:
Chemical Name:	L52715
Synonyms:	lipid 52715
SMILES:	OCCN(CCCCCC(=O)OCCC(OCCC(CCCC)CCCC)OCCC(CCCC)CCCC)CCCCCCC(=O)OCCC(CCCC)CCCC
Formula:	C₅₁H₁₀₁NO₇
M.Wt:	840.4
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC68177	L52715	L52715 is a novel ionizable lipid developed by Shanghai Vitalgen, used to deliver mRNA.
DC67602	ILB-3132（E12LA6B603)	E12LA6B603（ILB3132，ILB-3132） is a novel ionizable amino lipid disclosed in patent WO2024198497A1, developed by MagicRNA, representing a highly efficient component for lipid nanoparticle (LNP) delivery systems.When formulated into LNPs, E12LA6B603 LNP achieves a remarkable 98.26% encapsulation efficiency for mRNA. It mediates superior in vitro transfection in dendritic cells (1.8E+05 intensity) and demonstrates best-in-class in vivo protein expression after intramuscular injection (2.2E+09 intensity). Most notably, in a B16-OVA melanoma model, therapeutic OVA-mRNA vaccines delivered by E12LA6B603 LNPs induced 100% complete tumor regression, highlighting its superior efficacy over benchmarks like DLin-MC3 and SM-102. Its biodegradable ester linkages and balanced structure make it a promising, potent candidate for next-generation mRNA vaccines and therapeutics.