DM-1(Mertansine)|cas 139504-50-0|DC Chemicals

Cas No.:	139504-50-0
Synonyms:	Mertansine; DM 1; Maytansinoid DM 1; 139504-50-0; UNII-DDZ29HGH0E; DM1 Compound;
SMILES:	SCCC(N(C(C(OC1CC(=O)N(C)C2=C(C(=CC(=C2)CC(C)=CC=CC(OC)C2(O)NC(OC(C2)C(C)C2OC12C)=O)OC)Cl)=O)C)C)=O
Formula:	C₃₅H₄₈ClN₃O₁₀S
M.Wt:	738.29
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine is an antibody-conjugatable maytansinoid that was developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery.
References:	[1]. Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules.

Cat. No.	Product name	Field of application
DC72886	Dox-btn2	Dox-btn2 is a biotinylated derivative of Doxorubicin, with a biotin label at the point of conjugation to doxorubicin at 3'-NH2. Dox-btn2 can be used for cell imaging. While Doxorubicin is mainly accumulated in the nucleus, while Dox-btn2 is mainly located in the cytoplasm.
DC45695	Thailanstatin A	Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC.
DC7648	PNU159682	PNU-159682 is a major bioactive metabolite of Nemorubicin in human liver microsomes; > 3,000-fold cytotoxic than its parent compound(MMDX and doxorubicin).
DC8241	Ansamitocin P-3	Ansamitocin P-3, a potent anti-tumor maytansinoid found in Actinosynnema pretiosum, is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29.
DC8540	DM-1(Mertansine)	A cytotoxic agent used in antibody-drug conjugates