Dibutyryl-cAMP (Bucladesine)|cas 16980-89-5|DC Chemicals

Cas No.:	16980-89-5
Chemical Name:	Adenosine,N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, sodium salt(1:1)
Synonyms:	Adenosine,N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, sodium salt(1:1);N6,2'-O-Dibutyryladenosine 3',5'-Cyclic Monophosphate Sodium Salt;Bucladesine;Bucladesine (sodium salt);Bucladesine Sodium Salt;CALCIUM DIBUTYRYL ADENOSINE CYCLOPHOSPHATE;dbcAMP-100X, dbcAMP concentration-100X;Dibutyryl-cAMP;Dibutyryl-cAMP, sodium salt;DC2797;Dibutyryl cAMP sodium salt;dibutyryl cyclic AMP sodium salt;Dibutyryl cyclic-AMP sodium salt;N6,2‘-O-Dibutyryladenosine 3’,5‘-cyclic monophosphate;N6,2′-O-Dibutyryladenosine 3′,5′-cyclic Monophosphate sodiuM salt;sodium bucladesine;Sodium dibutyryl cAMP;sodium N6,O2'-dibutyryl cyclic adenosinemonophosphate;sodium N6,O2'-dibutyryl-O3',O5'-hydroxyphosphoryl-adenosine;sodium salt of N6,2'-O-dibutyryl adenosine 3',5'-cyclic monophosphate;Adenosine,N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, monosodiumsalt (9CI);Butyramide, N-(9-b-D-ribofuranosyl-9H-purin-6-yl)-, cyclic hydrogen phosphate butyrate(ester), monosodium salt (8CI);4H-Furo[3,2-d]-1,3,2-dioxaphosphorin, adenosinederiv.;Bucladesine sodium;Dibutyryl3',5'-cyclic AMP sodium salt;Dibutyryl cyclic AMP monosodium salt;Dibutyrylcyclic AMP sodium;Monosodium dibutyryl cyclic AMP;N-6,O-2'-Dibutyryladenosine cyclic 3',5'-monophosphatesodium salt;N6,2'-O-Dibutyryl-3',5'-cyclic AMP sodium salt;N6,2'-O-Dibutyryladenosine-3',5'-monophosphate monosodium salt;N6,O2'-Dibutyryl-3',5'-cyclic AMP sodium salt;SodiumN6,2'-O-dibutyryladenosine 3',5'-cyclic phosphate;Sodium dibutyryl3',5'-cyclic AMP;ibutyryl cyclic AMP sodium;,5ÕDBcAMP-Na;N6-2ÕPrestwick_32;CAMP, DB-, NA;BUCLADESINE NA;dt5621sodiumsalt;DIB-3:5-CAMP, NA;DC 2797;Dibutyryl-cAMP sodiumsalt;Dibutyryl-cAMP sodium salt;bucladesinesodium
SMILES:	O=C(CCC)O[C@H]1[C@H](N2C(N=CN=C3NC(CCC)=O)=C3N=C2)O[C@@](CO4)([H])[C@@]1([H])OP4([O-])=O.[Na+]
Formula:	C₁₈H₂₃N₅O₈P-^.Na+^.H₂O
M.Wt:	509.3828
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Bucladesine sodium salt is a cell-permeable cyclic AMP (cAMP) analog that activates cAMP dependent protein kinase (PKA).

References:

[1]. Sharifzadeh, M., et al., Post-training intrahippocampal infusion of nicotine-bucladesine combination causes a synergistic enhancement effect on spatial memory retention in rats. Eur J Pharmacol, 2007. 562(3): p. 212-20. [2]. Azami, K., et al., The quantitative evaluation of cholinergic markers in spatial memory improvement induced by nicotine-bucladesine combination in rats. Eur J Pharmacol, 2010. 636(1-3): p. 102-7. [3]. Mafune, E., M. Takahashi, and N. Takasugi, Effect of vehicles on percutaneous absorption of bucladesine (dibutyryl cyclic AMP) in normal and damaged rat skin. Biol Pharm Bull, 1995. 18(11): p. 1539-43. [4]. Rundfeldt, C., et al., The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation. Arch Dermatol Res, 2012.

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