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| Cas No.: | 1351636-18-4 |
| Chemical Name: | Tirabrutinib free base |
| Synonyms: | ONO-4059,ONO 4059,ONO4059 |
| SMILES: | O=C1N([C@@H]2CCN(C(=O)C#CC)C2)C2C(=C(N=CN=2)N)N1C1C=CC(OC2C=CC=CC=2)=CC=1 |
| Formula: | C25H22N6O3 |
| M.Wt: | 454.49 |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Publication: | [1]. Burger JA. Bruton's tyrosine kinase (BTK) inhibitors in clinical trials. Curr Hematol Malig Rep, 2014 Mar, 9(1):44-9. [2]. Harriet S. Walter et al. A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature |
| Description: | Tirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM. |