PDM2|PDM 2

Cas No.:	688348-25-6
Synonyms:	PDM-2,PDM2,PDM 2,688348-25-6
SMILES:	Clc1ccc(cc1)\C=C/c1cc(Cl)cc(Cl)c1
Formula:	C₁₄H₉Cl₃
M.Wt:	283.6
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	PDM2 is a selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with an Ki of 1.2±0.4 nM.
Target:	Ki: 1.2±0.4 nM(AhR)[1]
In Vitro:	PDM2 (Compound 4b) exhibits a Ki of 1.2±0.4 nM for AhR and no affinity for estrogen receptor (ER), confirming that replacement of hydroxyl with chloride abolished binding on ER and increased dramatically the affinity for AhR[1].
References:	[1]. de Medina P, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91.

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