PF-9363|cas 2569009-58-9|DC Chemicals

Cas No.:	2569009-58-9
Chemical Name:	PF-9363
Synonyms:	Schembl22802418;PF-9363
SMILES:	S(C1C(=CC=CC=1OC)OC)(NC1C2C(=CC(CN3C=CC=N3)=CC=2ON=1)OC)(=O)=O
Formula:	C₂₀H₂₀N₄O₆S
M.Wt:	444.461003303528
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Shikhar S, et al. First-in-class KAT6A/KAT6B Inhibitor CTx-648 (PF-9363) Demonstrates Potent Anti-tumor Activity in ER+ Breast Cancer with KAT6A Dysregulation [2]. WO2020254946

Description:	PF-9363 (CTx-648) is a first-in-class potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer[1][2].
In Vivo:	PF-9363 shows strong anti-tumor activity in patient-derived xenograft models[1].
In Vitro:	PF-9363 (0~1 μM; 1 day; ZR75-1, T47D and MCF7 cells) down-regulates the expression of H3K23Ac biomarker[1]. PF-9363 leads to down regulation of a specific set of genes involved in ESR1 pathway, cell cycle and stem cell pathways. PF-9363 shows that the IC50 values for ZR75-1 and T47D are 0.3 nM and 0.9 nM[1]. Western Blot Analysis[1] Cell Line: ZR75-1, T47D and MCF7 cells Concentration: 0~1 μM Incubation Time: 1 day Result: Down-regulated the expression of H3K23Ac biomarker.

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