Vonafexor|PLX007(EYP-001)|CAS 1192171-69-9

Cas No.:	1192171-69-9
Chemical Name:	PLX007(EYP-001)
Synonyms:	PLX007，EYP001，EYP 001，EYP-001，PLX 007，PLX-007
SMILES:	O=C(C1=CC2=C(Cl)C(N3CCN(S(=O)(C4=C(Cl)C=CC=C4Cl)=O)CC3)=CC=C2O1)O
Formula:	C₁₉H₁₅Cl₃N₂O₅S
M.Wt:	489.76
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Joly S, et al. The selective FXR agonist EYP001 is well tolerated in healthy subjects and has additive anti-HBV effect with nucleoside analogues in HepaRG cells. J Hepatol 66(1):S690. [2]. Fiorucci S,et al. Bile acid modulators for the treatment of nonalcoholic steatohepatitis (NASH) [published online ahead of print, 2020 Jun 19]. Expert Opin Investig Drugs. 2020;1-10.

Description:	Vonafexor (EYP001) is a selective FXR agonist with anti-HBV effects[1][2].
References:	[1]. Joly S, et al. The selective FXR agonist EYP001 is well tolerated in healthy subjects and has additive anti-HBV effect with nucleoside analogues in HepaRG cells. J Hepatol 66(1):S690. [2]. Fiorucci S,et al. Bile acid modulators for the treatment of nonalcoholic steatohepatitis (NASH) [published online ahead of print, 2020 Jun 19]. Expert Opin Investig Drugs. 2020;1-10.

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Vonafexor(PLX007,EYP-001)