Rp-8-bromo-cAMPS

Cas No.:	925456-59-3
Chemical Name:	8-bromo-adenosinecyclic3',5'-[hydrogen[P(R)]-phosphorothioate],monosodiumsalt
Synonyms:	Rp-8-bromo-Cyclic AMPS (sodium salt);Rp-8-bromo-Cyclic AMPS;5'-cyclic monophosphorothioate;8-Bromoadenosine 3';RP-8-BR-CAMPS;8-BROMOADENOSINE 3';5'-CYCLIC MONOPHOSPHOROTHIOATE; RP-ISOMER;RP-8-BROMO-CAMPS;925456-59-3;Rp-8-bromo-cAMPS;Rp-isomer
SMILES:	BrC1=NC2=C(N=CN=C2N1[C@@H]1O[C@]2([H])CO[P@](S)(=O)O[C@@]2([H])[C@H]1O)N.[NaH]
Formula:	C₁₀H₁₂BrN₅NaO₅PS
M.Wt:	448.16531085968
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

In Vitro:

Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP.It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II from bovine heart.

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