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Home > Inhibitors & Agonists > Cell Cycle/DNA Damage > Checkpoint Kinase (Chk)

SB218078

Cat. No.: DC9924 Featured

Chemical Structure

135897-06-2

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Field of application

SB218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively).

Chemicals Properties Biological activity Related products COA MSDS Datasheet

Cas No.:	135897-06-2
Synonyms:	SB 218078,SB-218078
SMILES:	C1CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C1O2)C7=C53)C(=O)NC6=O
Formula:	C₂₄H₁₅N₃O₃
M.Wt:	393.39
Purity:	>98%
Sotrage:	4°C for 1 year, -20°C for more than 2 years

Description:

SB218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). Abrogates G2 cell cycle arrest caused by γ-irradiation and topoisomerase I inhibition. Potentiates cytotoxicity of DNA-damaging drugs, enhancing the efficacy of some chemotherapeutics.

Cat. No.	Product name	Field of application
DC9924	SB218078	SB218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively).

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.