SR 0987|SR0987|RORγ agonist

Cas No.:	303126-97-8
Chemical Name:	2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzamide
Synonyms:	SR 0987，SR-0987，SR0987，303126-97-8
SMILES:	ClC1=CC=CC=C1C(NC2=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C2)=O
Formula:	C₁₆H₁₀ClF₆NO₂
M.Wt:	397.7
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	SR0987 is a RORγt agonist, with an EC50 of 800 nM.
In Vitro:	SR0987 clearly shows a concentration dependent induction of reporter gene expression with an EC50 of ~800nM. SR0987 treatment results in a statistically significant reduction of the surface expression of PD-1 whereas desmostrol treatment shows no effect. Treatment with SR0987 and or desmosterol results in a trend towards increased IL17 production[1].

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