Seclidemstat（SP-2577）|LSD1 inhibitor

Cas No.:	1423715-37-0
Chemical Name:	N'-[(1E)-1-(5-chloro-2-hydroxyphenyl)ethylidene]- 3-(4-methylpiperazine-1-sulfonyl)benzohydrazide
Synonyms:	SP-2577,SP2577,SP 2577
SMILES:	O=C(N/N=C(C1=CC(Cl)=CC=C1O)\C)C2=CC=CC(S(=O)(N3CCN(C)CC3)=O)=C2
Formula:	C₂₀H₂₃ClN₄O₄S
M.Wt:	450.93
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Seclidemstat (SP-2577) is a potent LSD1 inhibitor, with a mean IC50 of 127 nM.
In Vivo:	Seclidemstat (Compound 2577) reduces tumor volume at 40, 80 mg/kg by i.p. and also shows such effect at 80 mg/kg via p.o. dosing.

Cat. No.	Product name	Field of application
DC11703	T-3775440 hydrochloride	T-3775440 hydrochloride is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM.
DC11400	Seclidemstat（SP-2577）	Seclidemstat(SP-2577) is a potent LSD1 inhibitor, with a mean IC50 of 127 nM.
DC7636	RN-1 Hydrochloride	RN-1 is an inhibitor of lysine specific demethylase 1 (LSD1); exhibits selectivity for LSD1 over monoamine oxidase (MAO)-A and MAO-B (IC50 values are 70 nM, 0.51 and 2.79 μM respectively.
DC5204	OG-L002	OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively.
DC7740	ML-324	ML-324 is a JMJD2 histone demethylase inhibitor (JMJD2 IC50 = 920 nM)
DC11106	Vafidemstat (ORY-2001)	Vafidemstat (ORY-2001) is an oral, brain penetrant drug that inhibits LSD1 and MAOB by reducing cognitive impairment, including memory loss and neuroinflammation. It also has neuroprotective effects.
DC10586	KDM4D-IN-1	KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC50 value of 0.41±0.03 μM.
DC7614	IOX1	IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases.
DC8491	GSK2879552	GSK2879552 is an orally available, irreversible, inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity.
DC8385	Disodium (R)-2-Hydroxyglutarate	Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.