Secoisolariciresinol Diglucoside|cas 148244-82-0|Supplied by DC Chem

Cas No.:	148244-82-0
Chemical Name:	Secoisolariciresinol diglucoside
Synonyms:	Seco-isolariciresinol diglucoside;SECO-ISOLARICIRESINOL DIGLUCOSIDE(SDG)(P);Secoisolariciresinol Diglucosi;2,3-Bis(3-methoxy-4-hydroxybenzyl)butane-1,4-diol 1,4-diglucoside;Flaxseed Extract;SDG,Seco-isolariciresinol diglucoside;Secoisolariciresinol Diglucoside;Secoisolariciresinol Diglucoside（SDG）;Flaxseed gum;Secoisolariciresinol Diglucoside;SDG;Secoisolarisiresinol diglucoside;T9281L29MV;Secoisolariciresinol diglycoside;Secoisolariciresinol-Diglucoside;C32H46O16;(R,R)-Secoisolariciresinol diglucoside;EBD2202224;Y0185;X1171;244S820;beta-D-Glucopyranose, diglycoside with 2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]-1,4-butanediol, [R-(R,R)]
SMILES:	O([C@@]1([H])[C@@]([H])([C@]([H])([C@@]([H])([C@@]([H])(C([H])([H])O[H])O1)O[H])O[H])O[H])C([H])([H])[C@]([H])(C([H])([H])C1C([H])=C([H])C(=C(C=1[H])OC([H])([H])[H])O[H])[C@@]([H])(C([H])([H])C1C([H])=C([H])C(=C(C=1[H])OC([H])([H])[H])O[H])C([H])([H])O[C@@]1([H])[C@@]([H])([C@]([H])([C@@]([H])([C@@]([H])(C([H])([H])O[H])O1)O[H])O[H])O[H]
Formula:	C₃₂H₄₆O₁₆
M.Wt:	686.6981
Purity:	>98%,Standard References Grade
Sotrage:	4 Degree for 1 year, -20 degree for more than 2 years

Description:	seco-Isolariciresinol Diglucoside, a synthetic lignin, which is derived from the natural plant flaxseed. seco-Isolariciresinol Diglucoside reduces asbestos-induced NLRP3 expression, and NF-κB activation in macrophages (MF). seco-Isolariciresinol Diglucoside also activates Nrf2.
Target:	NLRP3 NF-κB Nrf2
In Vitro:	seco-Isolariciresinol Diglucoside (LGM2605) is a nontoxic lignan with anti-inflammatory and antioxidant properties and is evaluated for protection from asbestos in murine peritoneal macrophages (MF). seco-Isolariciresinol Diglucoside significantly reduces NLRP3 ranging from 40 to 81%, IL-1β by 89-96%, and TNFα by 67-78%, as well as activated NF-κB by 48-49% while decreasing levels of nitrates/nitrites by 85-93%. seco-Isolariciresinol Diglucoside reduces asbestos-induced NLRP3 expression, proinflammatory cytokine release, NF-κB activation, and nitrosative stress in macrophages (MF) supporting its possible use in preventing the asbestos-induced inflammatory cascade leading to malignancy. seco-Isolariciresinol Diglucoside inhibits NF-κB expression and prevents asbestos-induced iNOS expression and nitric oxide production by murine peritoneal macrophages. seco-Isolariciresinol Diglucoside activates Nrf2 and induces the expression of cellular antioxidant and detoxification enzymes[1].
References:	[1]. Pietrofesa RA, et al. The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages. Oxid Med Cell Longev. 2017;2017:7395238.

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Secoisolariciresinol diglucoside