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| Cas No.: | 2230640-94-3 |
| Chemical Name: | (2-(Allylamino)-4-aminothiazol-5-yl)(5-fluorothiophen-2-yl)methanone |
| Synonyms: | (2-(Allylamino)-4-aminothiazol-5-yl)(5-fluorothiophen-2-yl)methanone;TT10 |
| SMILES: | S1C(=NC(=C1C(C1=CC=C(F)S1)=O)N)NCC=C |
| Formula: | C11H10FN3Os2 |
| M.Wt: | 283.345002651215 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | TT-10 is a novel multifaceted fluorinated compound with promising features of CM proliferative, antioxidant, and antiapoptotic activities in vitro. The intraperitoneal injection of TT-10 in mice after MI promoted CM proliferation and reduced infarct size and fibrosis, which resulted in amelioration of cardiac dysfunction. Stimulating endogenous CM proliferation and/or protection with TT-10 treatment may be a desirable strategy to complement current therapies for acute MI.TT-10 promoted cardiomyocyte proliferation and simultaneously exerted antioxidant and antiapoptotic effects in vitro. TT-10 treatment in mice ameliorated myocardial infarction–induced cardiac dysfunction at least in part via enhancing clonal expansion of existing cardiomyocytes with nuclear YES-associated protein expression. Stimulating cardiomyocyte proliferation and/or protection with TT-10 might complement current therapies for myocardial infarction. |