UNC0646(UNC-0646)|G9a and GLP inhibitor|supplier DC Chemicals

Cas No.:	1320288-17-2
Chemical Name:	UNC 0646,UNC0646,UNC-0646
Synonyms:	UNC 0646,UNC0646,UNC-0646
SMILES:	N1=C2C(C=C(OC)C(OCCCN3CCCCC3)=C2)=C(NC2CCN(C3CCCCC3)CC2)N=C1N1CCCN(C(C)C)CC1
Formula:	C₃₆H₅₉N₇O₂
M.Wt:	621.9
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

UNC0646 is a potent and selective G9a inhibitor with IC50 of 6 nM.UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50 values are 6 nM and 15 nM for G9a and GLP, respectively). UNC0646 potently blocks G9a/GLP methyltransferase activity in cells (IC50 = 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50 = 4.7 μM in MCF7 cells). UNC0646 is selective for G9a/GLP over a range of other protein lysine methyltransferases and protein arginine methyltransferases.

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