Ulixertinib (BVD-523, VRT752271)|DC Chemicals

Cas No.:	869886-67-9
Chemical Name:	Ulixertinib (BVD-523)
Synonyms:	BVD-523, BVD 523, BVD523, VRT752271, VRT752271, VRT 752271, Ulixertinib
SMILES:	N1C(C(=O)N[C@H](CO)C2C=C(Cl)C=CC=2)=CC(C2=CC(NC(C)C)=NC=C2Cl)=C1.Cl
Formula:	C₂₁H₂₂Cl₂N₄O₂
M.Wt:	433.33
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Ulixertinib (VRT752271) is a reversible, ATP-competitive inhibitor of ERK1 and ERK2 kinases, with IC50 of <0.3 nM against ERK2.
In Vivo:	In the pharmacokinetic study, the sensitivity and specificity of the assay are found to be sufficient for accurately characterizing the plasma pharmacokinetics of Ulixertinib in Balb/C mice[1].
In Vitro:	Ulixertinib (VRT752271) is a reversible, ATP-competitive inhibitor of ERK1 and ERK2 kinases, with IC50 of <0.3 nM against ERK2[2].

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