WF-47-JS03|CAS 0|DC Chemicals

Cas No.:
Chemical Name:	WF-47-JS03
SMILES:	NC(N1C(N=C2NC3CC(C)(C)N(C)C(C)(C)C3)=C(C4=CC(OC)=C(OC)C=C4)C=N1)=C2C5=CC=CC=C5
Formula:	C₃₀H₃₈N₆O₂
M.Wt:	514.66
Sotrage:	Powder-20°C3 years4°C2 yearsIn solvent-80°C6 months-20°C1 month

Cat. No.	Product name	Field of application
DC47314	TPX-0046	TPX-0046 is a novel RET/SRC inhibitor with a mean IC50 of 17 nM for RETG810R in Ba/F3 cell proliferation assay.,RET [1]() SRC [1]()
DC47129	Zeteletinib	Zeteletinib (BOS-172738) shows selective inhibitory activity against RET, PDGFR, KIT, NTRK and FLT3 kinases. Zeteletinib has antitumor activity.
DC47018	Vepafestinib	Vepafestinib (compound 6) is a RET inhibitor (extracted from patent WO2019039439).
DC40626	RET-IN-3	RET-IN-3 (compound 34) is a selective RETV804M kinase inhibitor, with an IC50 of 19 nM.
DC40625	WF-47-JS03	WF-47-JS03 is a potent and selective RET kinase inhibitor with IC50s of 1.7 nM and 5.3 nM for KIF5B-RET transfected Ba/F3 cells and CCDC6-RET transfected LC-2/ad lung cancer cells, respectively. WF-47-JS03 demonstrates >500-fold selectivity against kinase insert domain receptor (KDR). Effective brain penetration.
DC10058	BBT594	BBT594 (NVP-BBT594), is potent and selective inhibitor of RET and JAK2.