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Home > RNA Delivery > Cationic/Ionizable Lipids > Ionizable Lipids for in vivo CAR

A28-C6B2

  Cat. No.:  DC67450   Featured
Chemical Structure
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More than 5000 active chemicals with high quality for research!
Field of application
A28-C6B2 is a biodegradable ionizable lipid specifically engineered for spleen-targeted delivery. Through its unique branched structure, it bypasses hepatic uptake to achieve highly efficient transfection of F4/80+ macrophages and CD11c+ dendritic cells within the spleen. This lipid remains neutral in the bloodstream to minimize non-specific interactions, while undergoing protonation in the acidic environment of the endosome to facilitate nucleic acid release, thereby significantly enhancing the potency of mRNA vaccines and immunotherapies.
Chemicals PropertiesBiological activity Related products COA MSDS Datasheet
Cas No.:
Chemical Name: A28-C6B2
Synonyms: A28C6B2， A28 C6B2
SMILES: CCCCCCC(COC(CCCCCN(CCCCCC(OCC(CCCC)CCCCCC)=O)CCCCCO)=O)CCCC
Formula: C41H81NO5
M.Wt: 668.1
Purity: ELSD-HPLC>95%
Sotrage: 1 year -20°C
Publication: Ren, Y., Zeng, L., Tang, Y., et al. Enhancing spleen-targeted mRNA delivery with branched biodegradable tails in lipid nanoparticles. J. Mater. Chem. B.
Cat. No. Product name Field of application
DC67450 A28-C6B2 A28-C6B2 is a biodegradable ionizable lipid specifically engineered for spleen-targeted delivery. Through its unique branched structure, it bypasses hepatic uptake to achieve highly efficient transfection of F4/80+ macrophages and CD11c+ dendritic cells within the spleen. This lipid remains neutral in the bloodstream to minimize non-specific interactions, while undergoing protonation in the acidic environment of the endosome to facilitate nucleic acid release, thereby significantly enhancing the potency of mRNA vaccines and immunotherapies.
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Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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