Ac-YVAD-cmk|CAS 178603-78-6|DC Chemicals

Cas No.:	178603-78-6
Chemical Name:	L-Alaninamide,N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-
Synonyms:	Ac-Tyr-Val-Ala-Asp-chloromethylketone;Ac-Tyr-Val-Ala-Asp-CMK;AC-YVAD-CMK;L-Alaninamide,N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-;N-Ac-Tyr-Val-Ala-Asp-CMK;AC-TYR-ALA-ASP-CHLOROMETHYLKETONE;AC-TYR-VAL-ALA-ASP-CH2CL;AC-YVAD-CHLOROMETHYLKETONE;AC-YVKD-CMK;ICE INHIBITOR II;IL-1BETA CONVERTING ENZYME INHIBITOR II;PASE-1 INHIBITOR II;N-Acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-L-alaninamide;N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketone;CASPASE-1 INHIBITOR II
SMILES:	CC([C@H](NC([C@@H](NC(C)=O)CC1=CC=C(O)C=C1)=O)C(N[C@H](C(N[C@H](C(CCl)=O)CC(O)=O)=O)C)=O)C
Formula:	C₂₄H₃₃ClN₄O₈
M.Wt:	540.99400
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC48112	Ac-YVAD-cmk	Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases.
DC45548	Boc-Asp(OMe)-fluoromethyl ketone	Boc-Asp(OME)-Fluoromethyl Ketone is a broad range caspase inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8.
DC5080	Belnacasan (VX-765)	VX-765 is a novel Caspase-1 inhibitor with an IC 50 of 0.8nM being investigated for the treatment of epilepsy, currently being developed by Vertex.
DC9283	Q-VD-Oph	Q-VD-Oph is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1,3,8, and 9.
DC9762	Emricasan	Emricasan (IDN-6556, PF-03491390) is a potent irreversible pan-caspase inhibitor.