DOTA-XYIMSR-01|CAS 2051527-54-7|DC Chemicals

Cas No.:	2051527-54-7
Chemical Name:	DOTA-XYIMSR-01
SMILES:	O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(NCCOCCOCCNC([C@@H](NC(C[C@@H](C(O)=O)NC(C[C@@H](C(O)=O)NC(CCC(C)(C2=CC=C(O)C=C2)C3=CC=C(O)C=C3)=O)=O)=O)CCCCN4C=C(CCCC(NC5=NN=C(S(=O)(N)=O)S5)=O)N=N4)=O)=O)CC1
Formula:	C₆₁H₈₈N₁₆O₂₂S₂
M.Wt:	1461.58
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC44166	EMAC10101d	EMAC10101d is a potent and selective toward hCA II inhibitor, with a Ki of 8.1 nM.
DC76843	Acetazolamide sodium	Acetazolamide sodium is an inhibitor of carbonic anhydrase (CA) IX with an IC50 of 30 nM for hCA IX and also inhibits hCA II with an IC50 of 13 nM. It possesses diuretic, antihypertensive, and anti-gonococcal properties.
DC76842	SH7s	SH7s is a potent carbonic anhydrases inhibitor, with Kis of 15.9 and 55.2 nM for hCA IX and hCA XII, respectively. SH7s is also a hypoxia-mediated chemo-sensitizing agent in colorectal cancer cells.
DC76841	DOTA-XYIMSR-01	DOTA-XYIMSR-01 is a molecular probe targeting CAIX that can be labeled with 177Lu for the inhibition and localization of malignant gliomas. The uptake of [177Lu] Lu-XYIMSR-01 in U87MG tumors is 6.19 % of the injected dose per gram (% ID/g), and the tumor-to-muscle uptake ratio is 20.14. In the orthotopic glioma model, combined injection with Temozolomide, is a Vps34 inhibitor.
DC76840	Chlorzolamide	Chlorzolamide (CL 13580) is a carbonic anhydrase (CA) inhibitor. Chlorzolamide has an effect on the skeletal muscle of rats, which can reduce the tetanic contraction force of soleus and extensor digitorum longus and prolong the relaxation time and peak time of muscle contraction. In addition, Chlorzolamide inhibits tumor cell proliferation and has antitumor activity.
DC76839	(Rac)-Sezolamide	(Rac)-Sezolamide (MK-927 (free base); (Rac)-MK 417 (free base)) is a carbonic anhydrase inhibitor (CAI) (Ki: 12.0 nM). (Rac)-Sezolamide has a topical intraocular pressure (IOP) lowering effect. (Rac)-Sezolamide can be used in glaucoma research.
DC72370	VM4-037	VM4-037 can be used for the synthesis of VM4-037(18F). VM4-037(18F) is a fluorinated PET imaging agent for carbonic anhydrase IX.
DC71807	Phenylsulfamide	Phenylsulfamide (Compound 10) is a human carbonic anhydrase-II (hCA-II) inhibitor with a Kd of 45.50 μM and a Ki of 79.60 μM.
DC71806	Disulfamide	Disulfamide, an orally active diuretic, is a carbonic anhydrase inhibitor with the IC50 value of 0.07 μM. Disulfamide leads to diuresis by inhibiting carbonic anhydrase and preventing the reabsorption of sodium and bicarbonate in the proximal tubule.
DC71380	Clofenamide	Clofenamide (Aquedux) is a carbonic anhydrase (CA) inhibitor. Clofenamide exhibits diuretic activity.