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Home > RNA Delivery > Cationic/Ionizable Lipids

E12CA1A3

  Cat. No.:  DC66221  
Chemical Structure
2778182-26-4
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Field of application
E12CA1A3 is an ionizable cationic lipid (pKa = 6.4) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 LNPs containing E12CA1A3 and encapsulating an mRNA reporter induce luciferase reporter expression in mouse bone marrow-derived dendritic cells (BMDCs) and mice. LNPs containing E12CA1A3 are cleared more rapidly from the liver than LNPs containing DLin-MC3-DMA (Item No. 34364) in mice.
Chemicals PropertiesBiological activity Related products COA MSDS Datasheet
Cas No.: 2778182-26-4
Chemical Name: E12CA1A3
Synonyms: 2-hexyl-decanoic acid, 2-[4-(dimethylamino)-1-oxobutoxy]dodecyl ester,E12CA1-A3， E12-CA1-A3， E12-CA1A3
SMILES: CCCCCCC(CCCCCCCC)C(OCC(CCCCCCCCCC)OC(CCCN(C)C)=O)=O
Formula: C34H67NO4
M.Wt: 553.9
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Cat. No. Product name Field of application
DC66221 E12CA1A3 E12CA1A3 is an ionizable cationic lipid (pKa = 6.4) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 LNPs containing E12CA1A3 and encapsulating an mRNA reporter induce luciferase reporter expression in mouse bone marrow-derived dendritic cells (BMDCs) and mice. LNPs containing E12CA1A3 are cleared more rapidly from the liver than LNPs containing DLin-MC3-DMA (Item No. 34364) in mice.
DC80070 A2-Iso5-2DC18 A2-Iso5-2DC18 is a top-performing lipid for mRNA delivery in bone marrow-derived dendritic cells (BMDCs), BMDMs and HeLa cells.
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Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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