GSK2646264|CAS 1398695-47-0|DC Chemicals

Cas No.:	1398695-47-0
Chemical Name:	1H-3-Benzazepine, 2,3,4,5-tetrahydro-7-[2-methoxy-6-[(4-methyl-2-pyridinyl)methoxy]phenyl]-
Synonyms:	1H-3-Benzazepine, 2,3,4,5-tetrahydro-7-[2-methoxy-6-[(4-methyl-2-pyridinyl)methoxy]phenyl]-
SMILES:	N1CCC2=CC(C3=C(OCC4=NC=CC(C)=C4)C=CC=C3OC)=CC=C2CC1
Formula:	C₂₄H₂₆N₂O₂
M.Wt:	374.48
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC70457	GSK2646264	GSK2646264 (GSK-2646264) is a potent, selective Spleen Tyrosine Kinase (Syk) inhibitor with pIC50 of 7.1, >300-fold selectivity over Autota B; inhibits anti-IgM induced Erk1/2 phosphorylation in Ramos B cells with pIC50 of 6.7.
DC10523	TAK-659 HCl	TAK-659 hydrochloride is a potent, selective and orally available spleen tyrosine kinase (Syk) inhibitor with an IC50 of 3.2 nM.
DC9759	RO0921	RO0921 is a novel, potent SYK inhibitor.
DC1013	R788 disodium (Fostamatinib)	R935788 (Fostamatinib disodium, R788) is a Syk inhibitor with IC50 of 41 nM.
DC9841	Fostamatinib(R788)	R788 (Fostamatinib), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.
DC8733	R406	R406 is a potent Syk inhibitor with IC50 of 41 nM and also potently inhibits Flt3.
DC1014	R406 free base	R406 is a potent Syk inhibitor with IC50 of 41 nM and also potently inhibits Flt3.
DC10660	BAY 61-3606 free base	BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
DC9632	BAY 61-3606 (dihydrochloride)	BAY 61-3606 2Hcl is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.