NUCC-0200590|CAS 1060461-67-7|DC Chemicals

Cas No.:	1060461-67-7
Chemical Name:	NUCC-0200590
Synonyms:	NUCC0200590,NUCC 0200590
SMILES:	CN1CCN(CC2=CC(C3=CC=C(F)C=C3)=CC=C2OCC(=O)NCC2=CC=C(Cl)C=C2)CC1
Formula:	C₂₇H₂₉ClFN₃O₂
M.Wt:	482

Cat. No.	Product name	Field of application
DC73619	Org 34167	Org 34167 HCl salt is a broad-spectrum inhibitor of HCN channels with IC50 of 23.4, 8.2 and 9.2 uM for HCN1, HCN2 and HCN4 channels, respectively, slowing activation and causing a hyperpolarising shift in voltage-dependence of activation.
DC73618	NUCC-0200590	NUCC-0200590 is a small-molecule inhibitor of the TRIP8b-HCN interaction with IC50 of 7.0 uM in AlphaScreen assays, effectively disrupts the TRIP8b-HCN interaction in vitro and in vivo.
DC70477	EC18 HCN inhibitor	EC18 HCN inhibitor is a HCN channel inhibitor. EC18 acts as a potent HCN4 inhibitor in a human iPSC-derived sinus node model with proven HCN4 expression. EC18 is an attractive pharmacological tool, enabling HCN channel-modulation studies with some specificity for HCN4 (EC50 [HCN4] = 3.98 ± 1.16 µM) over HCN1 (EC50 = 21.00 ± 3.98 µM) and HCN2 (EC50 = 19.35 ± 4.48 µM). EC18 abolishes HCN4 triggered pace making in a human iPSC (hiPSC) pacemaker model.