Vazegepant|CAS 1337918-83-8|DC Chemicals

Cas No.:	1337918-83-8
Chemical Name:	Vazegepant
SMILES:	CN1CCC(N2CCN(C([C@H](NC(N3CCC(C4=CC(C=CC=C5)=C5NC4=O)CC3)=O)CC6=CC(C=NN7)=C7C(C)=C6)=O)CC2)CC1
Formula:	C₃₆H₄₆N₈O₃
M.Wt:	638.80
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Leonard KA, et al. Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease. J Med Chem. 2020 Mar 26;63(6):2915-2929. [2]. Gene M Dubowchik,Charles M Conway,Alison W Xin.Blocking the CGRP Pathway for Acute and Preventive Treatment of Migraine: The Evolution of Success.

Description:	Vazegepant is the first intranasal CGRP receptor antagonist for the study the acute research of migraine[1][2].
References:	[1]. Leonard KA, et al. Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease. J Med Chem. 2020 Mar 26;63(6):2915-2929. [2]. Gene M Dubowchik,Charles M Conway,Alison W Xin.Blocking the CGRP Pathway for Acute and Preventive Treatment of Migraine: The Evolution of Success.

Cat. No.	Product name	Field of application
DC48154	SUN B8155	SUN B8155, a non-peptide agonist of calcitonin (CT) receptor, selectively mimics the biological actions of calcitonin. Calcitonin, a 32-amino acid peptide hormone secreted mainly from the thyroid gland, plays an important role in maintaining bone homeostasis.
DC47057	Vazegepant	Vazegepant is the first intranasal CGRP receptor antagonist for the study the acute research of migraine.
DC46162	Vazegepant hydrochloride	Vazegepant (BHV-3500) hydrochloride is a highly soluble CGRP receptor antagonist. Vazegepant hydrochloride is the first intranasal gepant for migraine. Vazegepant hydrochloride may be helpful in effective management of COVID-19 associated pulmonary inflammation.
DC9396	Olcegepant	Olcegepant(BIBN 4096; BIBN 4096BS) is the first potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor(IC50= 0.03 nM).