WX-02-23|CAS 2929223-35-6|DC Chemicals

Cas No.:	2929223-35-6
Chemical Name:	WX-02-23
Synonyms:	EX-A13714;1-((1R,3S)-1-(Benzo[d][1,3]dioxol-5-yl)-3-(morpholine-4-carbonyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)prop-2-en-1-one;WX-02-23;2929223-35-6;SCHEMBL25199525
SMILES:	O=C([C@@H]1CC2C3C=CC=CC=3NC=2[C@@H](C2=CC=C3C(=C2)OCO3)N1C(C=C)=O)N1CCOCC1
Formula:	C₂₆H₂₅N₃O₅
M.Wt:	459.493806600571
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC39709	Lenalidomide-Br	Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs.
DC81747	WX-02-23	WX-02-23 is a small-molecule probe that stereoselectively and site-specifically binds to C258 of FOXA1 and C1111 of SF3B1. WX-02-23 remodels FOXA1's chromatin binding and pioneer activity in a DNA-dependent manner, disrupts spliceosome assembly, and enhances the thermal stability of SF3B1. WX-02-23 inhibits tumor cell proliferation and induces apoptosis. WX-02-23 can be used for research on cancers such as prostate cancer.
DC72888	Z0933M	Z0933M is a potent S phase kinase-associated protein 1 (Skp1) inhibitor with Kd of 54 nM, potently inhibits Skp1-F-box protein-protein interactions with Ki value of 231 nM in FP-based in vitro competition assays.
DC42464	CRBN modulator-1	CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM.
DC11565	E3 Ligase Ligand 2	E3 ligase Ligand 2 is a Ligand for E3 Ligase used in PROTAC technology.