Inhibitor of HIV-reverse transcriptase activity

Novel AKAP1/PKA modulator, inducing UCP1 expression and thermogenesis

Novel anti-Alzheimer’s agent, inhibiting amyloid β aggregation, β-secretase, and tau aggregation

Novel near-infrared (NIR) probe for imaging β-amyloid (Aβ) plaques or Tau tangles

Novel potent anticancer agent, inhibiting the growth of CRC bulk and sensitized FOLFOX-resistant cells

Natural inhibitor of glutamic oxaloacetate transaminase 1 (GOT1), suppressing glutamine metabolism, making PDAC cells sensitive to oxidative stress and inhibiting cell proliferation, exhibiting potent in vivo antitumor activity in an SW1990-cell-induced x

Natural luciferase inhibitor

Natural inhibitor of pollen development in Arabidopsis thaliana, also inhibiting dihydroxy-acid dehydratase (DHAD)

Natural antineoplastic agent, targeting cathepsin and inducing autophagy effects in breast cancer cells

Novel cholecystokinin antagonist

Novel cholecystokinin antagonist

Selective antagonist for the cholecystokinin receptor CCKA

Novel potent Aspergillus hyphal growth inhibitor

Novel long-acting muscarinic antagonist (LAMA), showing more selective inhibition of bronchoconstriction against salivation and more rapid onset of action than tiotropium bromide

Novel tropomyosin-related kinase A (TrkA) inhibitor for the oral treatment of pain due to osteoarthritis of the knee

Novel dual A2A/A1 AR antagonist

Novel antifungal agent against Aspergillus isolates

Selective progesterone receptor modulator

Novel slow-onset, tight binding, potent asparagine synthetase (ASNS) inhibitor

Novel potent GPR17 agonist

Novel Permanently-charged Sodium Channel Blocker, Showing Robust Efficacy, a Rapid Onset and Long Duration of Action

Novel, Potent, Selective, and Direct Acid Sphingomyelinase (ASM) Inhibitor with Antidepressant Activity

Novel modulator of acetylcholine receptor function, promoting the in vitro relaxation of β2-adrenoreceptor desensitized tracheas

Novel, Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitor, Modulating Brain Inflammation In Vivo

Natural Suppressor of MMP-2-Mediated Migration and Invasion by Targeting FAK and JAK-STAT Signaling Cascades

Novel inhibitor of inositol-requiring enzyme 1 (IRE-1), also inhibiting G protein-coupled receptor kinase 6 (GRK6)

Novel angiogenesis inhibitor, directly binding to acid ceramidase 1 (ASAH1)

Selective inhibitor of aurora kinases (AKs)

Novel Receptor-interacting Protein Kinase 2 (RIP2) Inhibitor

Novel GPR40 agonist