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Inhibitors & Agonists

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Cat. No. Product Name Field of Application Chemical Structure
DC80120 7-APDB hydrochloride
7-APDB hydrochloride is a benzofuran compound and can be used for the research of neurological disease.
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DC80119 7.9 MAG
7.9 MAG is a non-monoolein lipid and acts as a detergent for crystallization.
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DC80118 6-Nitroquipazine
6-Nitroquipazine (DU24565) is a potent and selective 5-HT transporter inhibitor, with a Ki of 0.17 nM. 6-Nitroquipazine can be used in the research of psychiatric disorders such as depression.
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DC80117 6-Iodonordihydrocapsaicin
6-Iodonordihydrocapsaicin is a TRPV1 antagonist. 6-Iodonordihydrocapsaicin functionally blocks TRPV1-mediated responses, including capsaicin-induced ion currents in dorsal root ganglion neurons and distension-induced firing of jejunal spinal afferent fibers in mice. 6-Iodonordihydrocapsaicin can be used in the research of visceral pain and anxiety disorders.
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DC80116 6‑Hydroxy‑FAD
6-hydroxy-FAD is the dominant cofactor of H. insolens Cellobiose dehydrogenases. the activity of Cellobiose dehydrogenases containing 6-hydroxy-FAD is lower than that of the enzyme reconstituted with normal FAD.
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DC80115 6ECA
6ECA is a selective TGR5 receptor activator with an EC50 of 3.44 μM. 6ECA shows no significant activity at FXR. 6ECA can be used for the study of diabesity.
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DC80114 6-Amino-1-hexanethiol hydrochloride
6-Amino-1-hexanethiol hydrochloride is a PROTAC linker that can be used in the synthesis of PROTACs.
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DC80113 5β-Cholanic acid-3,6-dione
5β-Cholanic acid-3,6-dione (3,6-Diketo-LCA) is a similar substance to Lithocholic acid (LCA). 5β-Cholanic acid-3,6-dione cannot activate the Vitamin D receptor (VDR), and can be used as a negative control for studying the relationship between LCA derivatives and VDR.
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DC80112 5-trans Prostaglandin D2
5-trans Prostaglandin D2 is a prostaglandin D2 receptor agonist.
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DC80111 5-Hydroxymethyl flucloxacillin
5-Hydroxymethyl flucloxacillin is an active metabolite of Flucloxacillin. 5-Hydroxymethyl flucloxacillin exhibits antibacterial activity.
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DC80110 5-HT7R antagonist 5
5-HT7R antagonist 5 (Compound (R)-4) is a 5-HT7AR antagonist, with a Ki of 46.4 nM. 5-HT7R antagonist 5 shows anticancer effects against prostate cancer.
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DC80109 5-HT7/5-HT2A receptor antagonist 1
5-HT7/5-HT2A receptor antagonist 1 is a high-affinity, orally active, brain-penetrant 5-HT7 and 5-HT2A receptor ligand having a pKi = 8.1 at both receptors. 5-HT7/5-HT2A receptor antagonist 1 behaves as an antagonist in an in vitro functional assay for 5-HT2A and as an inverse agonist in an in vitro functional assay for 5-HT7. 5-HT7/5-HT2A receptor antagonist 1 blockade of 5-Carboxamidotryptamine (5-CT) induced hypothermia in rats, and blockade of 2,5-dimethoxy-4-iodoamphetamine (DOI) induced head-twitches in mice. 5-HT7/5-HT2A receptor antagonist 1 occupied 5-HT2A receptor binding sites in the frontal cortex of the rat brain. 5-HT7/5-HT2A receptor antagonist 1 can be used for the study of Neurological diseases.
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DC80104 5-HT2A&5-HT2C agonist-3
5-HT2A&5-HT2C agonist-3 (compound 4e) is an orally bioavailable and blood-brain barrier penetrant agonist of 5-HT2A and 5-HT2C. 5-HT2A&5-HT2C agonist-3 increases intracellular calcium levels in cells overexpressing 5-HT2A or 5-HT2C receptors, and shows no activity against 5-HT2B receptors. 5-HT2A&5-HT2C agonist-3 can be used for the research of neuropsychiatric disorders.
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DC80103 5-HT2A agonist 8
5-HT2A agonist 8 (Compound 67) is a 5-HT2A agonist, with an EC50 of 4 nM. 5-HT2A agonist 8 can be used in the research of neuropsychiatric and neurodegenerative diseases.
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DC80102 5-Formyl-2-hydroxy-2,4-heptadienedioic acid
5-Formyl-2-hydroxy-2,4-heptadienedioic acid (compound II) is a product of metu-cleavage of 3,4-dihydroxyphenylacetate.
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DC80100 5-Diazomethane quinoxaline
5-Diazomethane quinoxaline is a novel derivatization reagent. 5-Diazomethane quinoxaline is used for the detection of phosphorylated metabolites.
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DC80098 5-CNAC (disodium)
5-CNAC disodium is an orally active enhancer of absorption, with no pharmacological activity on its own. 5-CNAC disodium can significantly enhance the absorption efficiency of the drug (such as Salmon calcitonin) when administered together with it in the gastrointestinal tract. 5-CNAC disodium binds reversibly and non-covalently to peptide drugs, protecting them from degradation by gastrointestinal enzymes, increasing their lipid solubility, promoting passive transcellular absorption, and not damaging the integrity of the intestinal epithelium. 5-CNAC disodium can be used in the research of adjuvants for orally administered peptide agents.
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DC80097 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole is a nucleoside metabolite.
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DC80096 5-Amino-2'-deoxyuridine
5-Amino-2'-deoxyuridine is a thymidine analogue and substrate for chemical reaction. 5-Amino-2'-deoxyuridine can be use in the preparation of labeled probes for DNA microarray analysis.
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DC80095 501A054
501A054 is an autophagy activator. 501A054 induces autophagy-dependent cell death via autophagy activation. 501A054 can be used in studies on autophagy regulation such as cervical cancer.
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DC80094 4-PSQ
4-PSQ is an orally active neuroprotective agent. 4-PSQ possesses both antioxidant and anti-inflammatory activities. 4-PSQ improves cognitive impairment and depressive- and anxiety-like emotional abnormalities in mice by regulating the activity of Na+, K+-ATPase, the NFκB signaling pathway, and the expression of p21. 4-PSQ can be used for the research of neurological diseases.
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DC80093 4-Nitrophthalic acid
4-Nitrophthalic acid is a metal-organic framework (MOF).
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DC80092 4-Methylthio-2-oxobutanoic acid
4-Methylthio-2-oxobutanoic acid (MTOB) is an ornithine decarboxylase inhibitor. 4-Methylthio-2-oxobutanoic acid reduces ornithine decarboxylase protein levels and enzymatic activity. 4-Methylthio-2-oxobutanoic acid is formed in cells in the Met salvage pathway from methylthioadenosine. 4-Methylthio-2-oxobutanoic acid inhibits cancer cells growth. 4-Methylthio-2-oxobutanoic acid can be used for the research of cancer.
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DC80091 4-Methylbenzyl cyanide
4-Methylbenzyl cyanide is an organic chemical probe used to study intramolecular rotation properties. 4-Methylbenzyl cyanide is promising for research of NMR spectroscopy and physical chemistry research on molecular dynamics.
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DC80090 4-Methyl-3-hydroxyanthranilic acid
4-Methyl-3-hydroxyanthranilic acid (MHA) is a key precursor for the synthesis of Actinomycin D.
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DC80089 4-Methoxyphthalic acid
4-Methoxyphthalic acid is a metal-organic framework (MOF).
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DC80087 4-Hydroxytryptophol
4-Hydroxytryptophol is an in vitro metabolite of psilocin, can be found in human liver microsomes and recombinant monoamine oxidase A systems. 4-Hydroxytryptophol is not detected in in vivo samples from mice or humans.
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DC80086 4-Hydroxyphenylacetylglutamic acid
4-Hydroxyphenylacetylglutamic acid is a metabolite of Morus alba L.
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DC80084 4-Hydroxyalprenolol
4-Hydroxyalprenolol (Alp2b) is a metabolite of β-receptor blocker Alprenolol.
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DC80083 4-Guanidinobutanal
4-Guanidinobutanal is a nucleoside metabolite.
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