Selective kynurenine aminotransferase 2 (KAT2) inhibitor

PET precursor for NNC112

Less active enantimer of Bambuterol

Potent and selective inhibitor of PI 3-kinase ß (PI3-Kß)

Potent beta-adrenoreceptor antagonist

Natural flavonoid from the stem bark of Bolusanthus speciosus

The First Selective Orthosteric GluK3 Antagonist

Novel potent orally available allosteric TSH receptor (TSHR) agonist

Novel σ Receptor Agonist with Neuroprotective Effect

Elongation factor P (EF-P) fuction modifier

More active enantiomer of praziquantel as potent anthelmintic

Enhancer of memory function

Selective Dopamine D3 Receptor Antagonist

More active R diastereomer of Pam2Cys, acting as a potent TLR2 agonist

Inhibitor of dopamine beta-hydroxylase

Competitive Specific Inhibitor of sphingosine kinase 2 (SK2)

R-Enantiomer of folcisteine, a plant growth regulator

Negative control for UNC6852

IMP-1710 (IMP1710) is a potent, selective, covalent UCHL1 inhibitor with IC50 of 38 nM.IMP-1710 demonstrated exquisite selectivity in a cross-screening against 20 DUBs.IMP-1710 can profile activity of endogenous UCHL1 with excellent selectivity in cell types including endothelial cells (EA.hy926) and adenocarcinoma human alveolar basal epithelial cells (A549).IMP-1710 demonstrated >50% fibroblast–myofibroblast transition (FMT) inhibition (IC50=740 nM) in idiopathic pulmonary fibrosis (IPF), as well as αSMA inhibition.IMP-1710 is a powerful and selective probe to explore UCHL1 activity with potential application to substrate identification, mode of action studies, and cellular target profiling.

Tematropium(CDDD3602) is a soft anticholinergics.

N-Type calcium channel inhibitor

Novel potent and selective oxytocin receptor antagonist

UoS12258 (UoS-12258) is a selective, positive allosteric modulator of the AMPA receptor with pEC50 of 5.6.

AM 103 is a potent and selective FLAP inhibitor, with an IC50 value of 4.2 nM.

Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist, also inhibits CYP2C9 and 4-hydroxylation with IC50 of 10.5 μM and 8.2 μM respectively.

DS-437 is a potent, selective, dual inhibitor of PRMT5 and PRMT7 with IC50 of 6.0 uM for both, DS-437 is inactive against 29 other human protein-, DNA-, and RNA-methyltransferases.

Bevurogant is a retinoid-related orphan receptor-gamma t (RORγt) antagonist. Bevurogant can be used for the research of chronic inflammatory diseases.

N-Formyl-Met-Leu-Phe, also known as fMLF, is a potent neutrophil chemoattractant and the reference agonist for the G protein-coupled N-formylpeptide receptor (FPR).

MOTS-c, a mitochondria-derived peptide (MDP), exerts antinociceptive and anti-inflammatory effects through activating AMPK pathway and inhibiting MAP kinases-c-fos signaling pathway.

TVB-3166 is an orally-available, reversible, potent, and selective fatty acid synthase (FASN) inhibitor with biochemical IC50 of 42 nM.