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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC34852 endo-BCN-PEG12-NHS ester
endo-BCN-PEG12-NHS ester is a PEG derivative containing an NHS ester group and a BCN group. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The BCN group can react with azide-tagged biomolecules. PEG Linkers may be useful in the development of antibody drug conjugates and drug delivery methods.
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DC34848 endo-BCN-PEG12-acid
endo-BCN-PEG12-acid is a PEG derivative containing a BCN group with a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The BCN group can react with azide -tagged biomolecules. PEG Linkers may be useful in the development of antibody drug conjugates and drug delivery methods.
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DC34847 endo-BCN-PEG8-acid
endo-BCN-PEG8-acid is a PEG derivative containing a BCN group witha terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The BCN group can react with azide -tagged biomolecules. PEG Linkers may be useful in the development of antibody drug conjugates and drug delivery methods.
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DC34842 APN-C3-PEG4-alkyne
APN-C3-PEG4-alkyne is part of a new class of thiol-specific conjugation reagents consisting of a thiol-reactive 3-arylpropiolonitrile (APN) group. The APN group allows the targeted coupling of thiols in biomolecules, and results in stable thioether linkages without the risk of subsequent side reactions that can occur with maleimides.
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DC34783 Propargyl-PEG4-CH2CO2-NHS
Propargyl-PEG4-CH2CO2-NHS is a PEG derivative containing a propargyl group and an NHS group. The hydrophilic PEG spacer increases solubility in aqueous media. This reagent has a terminal NHS ester and is an amine reactive reagent for derivatizing peptides, antibodies, amine coated surfaces etc. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-NHS ester Click Chemistry to yield a stable triazole linkage.
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DC34749 DSSeb Crosslinker
DSSeb Crosslinker, or Disuccinimidyl sebacate, is a homobifunctional crosslinking reagent which is cell membrane permeable. DSSeb Crosslinker is useful in protein crosslinking and making antibody drug conjugates (ADCs).
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DC34694 Prothoate
Prothoate is an insecticide. This molecule can be used in analytical study to detect multi-residue of organophosphorus pesticide.
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DC34687 Leptophos
Leptophos is an organophosphate insecticide.
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DC34684 Hydrocortisone hemisuccinate anhydrous
Hydrocortisone hemisuccinate anhydrous is an anti-inflammatory agent.
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DC34617 ONO-8711
ONO-8711 is a selective EP1 antagonist.
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DC34616 NADA-green
NADA-green is a fluorescent D-amino acid for labeling peptidoglycans in live bacteria.
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DC34608 R-IMPP Hydrochloride
R-IMPP Hydrochloride is an anti-secretagogue of PCSK9, promoting uptake of LDL-C in hepatoma cells by increasing LDL-R levels and blocking PCSK9 translation.
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DC34589 FlAsH-EDT2
FlAsH-EDT2 is a pro-fluorescent, membrane-permeable, covalent CCPGCC targeted probe.
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DC34571 TL12186
TL12-186 is a multikinase degrading PROTAC.
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DC34511 FDG
Fluoroglutamine (2S,4R) is a Glutamine analog, not metabolized in the TCA cycle, but it can be incorporated into proteins and peptides. Fluoroglutamine (2S,4R) can be used as assess transporter (ASCT2) activity or protein synthesis rate.
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DC34414 U-99194 maleate
U-99194 maleate is a potent, selective D3 antagonist.
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DC34356 N-Acetylpurinomycin
N-Acetylpurinomycin is a selective CB2 receptor agonist.
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DC34324 Bz-423
Bz-423 is an F1F0-ATPase modulator. It acts by selectively killing autoimmune lymphocytes.
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DC34218 Cytochalasin D
Cytochalasin D is a fungal metabolite. It blocks formation of contractile microfilament structures, resulting in multinucleated cell formation, reversible inhibition of cell movement, and the induction of cellular extrusion. It also inhibits actin polymerization, DNA synthesis, sperm motility, glucose transport, thyroid secretion, and growth hormone release.
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DC34182 (R)-Citalopram oxalate
(R)-Citalopram oxalate is a less active enantiomer of Escitalopram Oxalate, a potent and selective inhibitor of serotonin reuptake.
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DC34092 AC30341
AC30341 is a PqsE inhibitor. It binds to the active center, inhibiting PqsE's thioesterase activity in cell-based and in vitro assays.
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DC34014 5-(N,N)-Dimethylamiloride Hydrochloride
5-(N,N)-Dimethylamiloride Hydrochloride is a Na(+)-H+ exchange inhibitor.
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DC34011 VPC-13566
VPC-13566 is an advanced BF3-specific small molecule that was previously reported to effectively inhibit AR transcriptional activity and to displace the BAG1L peptide from the BF3 pocket. VPC-13566 inhibits the growth of various prostate cancer cell lines, including an enzalutamide-resistant cell line, and reduces the growth of AR-dependent prostate cancer xenograft tumors in mice.
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DC34009 BDP 650/665 X NHS ester
BDP 650/665 is a borondipyrromethene dye with far red excitation and emission. The dye has a good molar extinction coefficient and emission quantum yield. The NHS ester can be conjugated with amine groups of proteins, peptides, and other molecules. The molecule contains an additional aminohexanoic acid linker.
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DC34008 BDP 630/650 X NHS ester
BDP 630/650 is a borondipyrromethene fluorophore that has a high molar extinction coefficient, excellent quantum yield, and a relatively long lifetime of the excited state. Due to it, this fluorophore is useful for fluorescence polarization assays that allow to detect binding between molecules. This is an amine reactive NHS ester. It contains an aminohexanoyl linker between the fluorophore and the reactive group.
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DC33960 5-isomer TAMRA amine
TAMRA (tetramethylrhodamine) is a well known fluorophore that has a long history of use in biomolecule labeling. TAMRA can serve as a FRET acceptor for FAM (fluorescein). TAMRA amine is a derivative having a primary amine group that can be conjugated with various electrophiles like activated esters, epoxides, etc., used in reductive amination reactions, and in enzymatic transamination.
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DC33959 Sulfo-Cyanine7 amine
Sulfonated, water-soluble, amino derivative of Cyanine7 NIR dye. This NIR dye amine can be used for the derivatization of various targets by the reaction with electrophilic groups, and also by enzymatical reactions involving transamination.
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DC33958 Sulfo-Cyanine5.5
Sulfo-Cyanine5.5 is a water soluble cyanine dye for far red / NIR applications such as in vivo imaging. The dye possesses four sulfonate groups that render it highly hydrophilic and water soluble. As well as other cyanines, sulfo-Cyanine5.5 has an outstanding extinction coefficient that makes it a bright fluorescent label for the far red region. This is an amine-containing fluorescent dye. The amine group is separated from the fluorophore by a relatively long linker that facilitates conjugation. The aliphatic primary amine group can be coupled with various electrophiles (activated esters, epoxides, etc), and also be used in enzymatic transamination labeling.
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DC33957 Sulfo-Cyanine5 amine
Water soluble amino dye for enzymatic transamination labeling, and other coupling with electrophiles. Cyanine5 is a popular fluorophore which is compatible with different fluorescence measuring instruments. Sulfo-Cyanine5 derivatives possess good water solubility.
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DC33956 Sulfo-Cyanine3 amine
A water soluble dye with amino group, useful for the conjugation with electrophiles, and for enzymatic transamination labeling. Sulfo-Cyanine3 is a sulfonated analog of Cy3, which is compatible with various fluorescence measuring equipment. The dye is highly photostable. It is also easily detectable by naked eye.
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