Unique inhibitor of MDM2, inhibiting MDM2-p53 interaction and promoting MDM2 degradation

Novel selective inhibitor of the CREB binding protein (CBP)

Novel potent inhibitor of CpFIKK catalytic activity

Novel non-RBD binding modulator to inhibit SARS-CoV-2 by prohibiting the conformational change of the spike (S) protein

Novel inhibitor of against human liver FBPase (IC50, 0.029±0.006 μM) and high selectivity relative to the other six AMP-binding enzymes, producing significant glucose-lowering effects on both type 2 diabetic KKAy mice and ZDF rats

Novel nonnucleoside reverse transcriptase inhibitor (NNRTI)

Potent PPARα agonist with a Ki of 10.8 nM

Novel Mdr1 P-glycoprotein substrate

Novel selective α5 GABA A receptor agonist

Inhibitor of Kv1.3 potassium ion channels

Inhibitor of glycogen phosphorylase; Antidiabetic

Novel potent and selective p38alpha inhibitor

Potent and selective leukotriene B4 antagonist

Novel viral propagation inhibitor, binding to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE), stabilizing the hairpin's folded state and reducing frameshifting efficiency in cells

Novel Potent Mitochondria-Targeted Photodynamic Therapy Anticancer Agent

Novel Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in Mycobacterium tuberculosis

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Preformed water-soluble complex of corticosterone and 2-hydroxypropyl-β-cyclode​xtrin

Selective glucocorticoid receptor antagonist

Novel class I mutation corrector, rescuing CFTR mutations in nucleotide-binding domain 1 (NBD1) by modulating proteostasis

Novel photoCORM, exhibiting good cellular uptake and real-time monitoring ability of CO uncaging by a color change approach in cancerous B16F10 cells

Natural potent cytotoxic agent against multiple cancer cell lines, acting on cells as a protein synthesis inhibitor, targeting the eukaryotic translation elongation factor 1A (eEF1A), a target shared by other lipophilic cyclic peptide natural products

Novel positive allosteric modulator of the GABA(B) receptor

Novel positive allosteric modulator of the GABA(B) receptor

Novel potent and selective melanocortin-4 receptor inhibitor, possessing 15-fold selectivity for the MC4R versus the MC3R

Novel fluorescent copper probe

A mixture of estrogen hormones used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women, being also used to replace estrogen in women with ovarian failure or other conditions tha

Natural triketide pyrone, functioning as a sulfate shuttle and its sulfated derivative being accepted as donor molecules by the PAPS-independent arylsulfate sulfotransferase (ASST) Cpz4 to yield sulfated caprazamycin intermediate

Novel inducer of Klotho (KL) expression

Dual inhibitor of phospholipid transfer protein and microsomal triglyceride transfer protein