Inducer of G2/M-phase cell cycle arrest and cell death in cancer cell lines

Inhibitor of tubulin polymerization; vascular disrupting agent (VDA)

Inhibitor of tubulin polymerization, preventing cancer cells from producing microtubules

Natural differentiation inducer of human promyelocytic leukemia cells

Novel potent and selective inhibitor of the interaction between Hsp47 and collagen

Novel potent and selective inhibitor of the interaction between Hsp47 and collagen

Novel potent and selective inhibitor of the interaction between Hsp47 and collagen

Natural lariat depsipeptide, inhibiting VEGFA/VEGFR2 expression and suppressing tumor growth in glioblastoma xenografts, targeting Sec61 to prevent biogenesis of secretory and membrane proteins

Novel inhibitor of mitogen-activated protein kinase (MAPK)

Novel potent RIPK1/necroptosis ligand, penetrate the blood-brain barrier

Novel and selective noncompetitive antagonist of the NMDA

N-methyl-D-aspartate (NMDA) receptor ligand, selectivity targeting the intrachannel PCP/ketamine/MK-801 site of NMDA receptor

Novel potent and selective blocker of the calcineurin-NFAT interaction (KD=16nM), preventing acute lung injury, being a promising novel treatment for ARDS and other inflammatory diseases

Novel partial blocker of GluK1, with GluK2 being unaffected

Novel blocker of binding of CXCL12 to CXCR4

Novel Zika virus (ZIKV) NS2B-NS3pro protease inhibitor

Novel Potent Inhibitor of the HIV-1 Nucleocapsid Protein

Novel Inhibitor for RNA-Dependent RNA Polymerase of Norovirus

Novel TRPV1 modulator, also modulating both CB1 and CB2 receptors

Selective and potent potentiator of nAChRs containing an α4

Novel allosteric modulator of the β2 adrenergic receptor (β2AR), binding to a pocket formed primarily by the cytoplasmic ends of transmembrane segments 1, 2, 6 and 7 as well as intracellular loop 1 and helix 8

Inhibitor of DprE1, an epimerase required for cell wall biosynthesis

Potent dual 5-lipoxygenase (5-LOX) inhibitor and platelet-activating factor (PAF) receptor antagonist

Novel SARS-CoV Mpro inhibitor which has its P1-phenylalanine residue bound to the relatively hydrophilic S1 pocket of the enzyme and yet exhibits a high inhibitory activity against SARS-CoV Mpro, with Ki = 2.24 ± 0.58 μM

Novel peptide STAT5 inhibitor, blocking IL-2/sIL-2Rα signaling and inhibiting T reg cell development

Novel ultrapotent and selective inhibitor of of human β-Factor XIIa

Novel Potent and Specific Target Of Rapamycin Complex 2 (TORC2) Inhibitor

Novel Hedgehog pathway inhibitor, revealing the receptor GPR39

Novel inhibitor of

Novel Epigenetic Inhibitor Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with In Vivo Efficacy in Multiple Myeloma