Novel dual A2A/A1 AR antagonist

Novel antifungal agent against Aspergillus isolates

Selective progesterone receptor modulator

Novel slow-onset, tight binding, potent asparagine synthetase (ASNS) inhibitor

Novel potent GPR17 agonist

Novel Permanently-charged Sodium Channel Blocker, Showing Robust Efficacy, a Rapid Onset and Long Duration of Action

Novel, Potent, Selective, and Direct Acid Sphingomyelinase (ASM) Inhibitor with Antidepressant Activity

Novel modulator of acetylcholine receptor function, promoting the in vitro relaxation of β2-adrenoreceptor desensitized tracheas

Novel, Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitor, Modulating Brain Inflammation In Vivo

Natural Suppressor of MMP-2-Mediated Migration and Invasion by Targeting FAK and JAK-STAT Signaling Cascades

Novel inhibitor of inositol-requiring enzyme 1 (IRE-1), also inhibiting G protein-coupled receptor kinase 6 (GRK6)

Novel angiogenesis inhibitor, directly binding to acid ceramidase 1 (ASAH1)

Selective inhibitor of aurora kinases (AKs)

Novel Receptor-interacting Protein Kinase 2 (RIP2) Inhibitor

Novel GPR40 agonist

Novel SHIP2 inhibitor, increasing Akt phosphorylation, glucose consumption, and glucose uptake in L6 myotubes, specifically upregulating the GLUT1 gene

Novel Foxo1 inhibitor, exerting anti-diabetic and anti-hypertriglyceridemic effects by improving blood glucose and triglyceride metabolism at the gene expression level

Second-generation potent orally-active thrombopoietin (TPO) receptor agonist

Novel GPR119 agonist, potentiating insulin secretion from rat islets and having potent anti-diabetic effects in ICR and diabetic db/db mice

Potent factor Xa inhibitor with significant oral anticoagulant activity

Inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake, significantly restoring decreased insulin-like growth factor 1 and fibroblast growth factor 2 mRNA levels in dorsal root ganglion and spinal cord, respectively

Inhibitor of D-amino acid oxidase (DAAO)

Novel Potent and Selective Inhibitor of CDC7 Kinase for the Treatment of Solid Cancers

Non-steroidal selective estrogen receptor modulator (SERM)

Inhibitor of the inflammatory responses via NF

The first human arylsulfatase A reversible inhibitor, impairing mouse oocyte fertilization

Selective alpha-7 agonist

Novel potent and selective BRAF inhibitor

Novel selective estrogen receptor degrader (SERD), inducing regression in a tamoxifen-resistant breast cancer xenograft

Novel dual inhibitor of the fatty acid amide hydrolase (FAAH) and the cyclooxygenase (COX) enzymes