Azeliragon HCl|CAS 1284150-65-7|DC Chemicals

Cas No.:	1284150-65-7
Chemical Name:	3-(4-(2-butyl-1-(4-(4-chlorophenoxy)phenyl)-1H-imidazol-4-yl)phenoxy)-N,N-diethylpropan-1-amine dihydrochloride
Synonyms:	Azeliragon HCl; Azeliragon hydrochloride; Azeliragon dihydrochloride; TTP488 HCl; TTP-488; TTP 488; PF-04494700; PF 04494700; PF04494700.
SMILES:	CCN(CC)CCCOC1=CC=C(C2=CN(C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3)C(CCCC)=N2)C=C1.[H]Cl.[H]Cl
Formula:	C₃₂H₄₀Cl₃N₃O₂
M.Wt:	605.041
Purity:	>98%
Sotrage:	-20℃ for 3 years in powder form

Description:

Azeliragon, also known as TTP488 and PF-04494700, is a potent and orally active RAGE inhibitor. RAGE (receptor for advanced glycation endproducts) is a pattern recognition receptor, which affects the movement of amyloid, an Alzheimer's-associated protein, into the brain. In preclinical studies, azeliragon decreased brain amyloid in mice and improved their performance on behavior tests. Azeliragon is a promising agent for for Alzheimer's disease and cerebral amyloid angiopathy.

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