AZ-8838|AZ 8838;AZ8838

Cas No.:	2100285-41-2
Chemical Name:	(S)-(4-fluoro-2-propylphenyl)(1H-imidazol-2-yl)methanol
Synonyms:	AZ 8838;AZ8838
SMILES:	[C@@H](C1=CC=C(F)C=C1CCC)(C1NC=CN=1)O
Formula:	C₁₃H₁₅FN₂O
M.Wt:	234.274
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AZ-8838 (AZ8838) is a potent, and selective PAR2 antagonist with Kd of 125 nM; shows excellent selectivity over PAR1 and PAR4 (>50 uM).

Cat. No.	Product name	Field of application
DC47359	SCH79797	SCH79797 is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. SCH79797 has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes.
DC47251	FR-171113	FR171113 is a specific and non-peptide thrombin receptor antagonist. FR171113 exhibits the antithrombotic effects of a PAR1 antagonist. FR171113 inhibits thrombin-induced platelet aggregation with an IC50 of 0.29 μM..
DC46522	Parstatin(mouse) TFA	Parstatin(mouse) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis.
DC46521	Parstatin(human) TFA	Parstatin(human) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis.
DC45574	Protease-Activated Receptor-1, PAR-1 Agonist TFA	Protease-Activated Receptor-1, PAR-1 Agonist TFA is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist TFA corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor.
DC45261	Parstatin(human)	Parstatin(human), a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis.
DC45260	Parstatin(mouse)	Parstatin(mouse), a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis.
DC45259	Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA	Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA is a proteinase-activated receptor (PAR-3) agonist peptide.
DC42021	Protease-Activated Receptor-3 (PAR-3) (1-6), human	Protease-Activated Receptor-3 (PAR-3) (1-6), human is a proteinase-activated receptor (PAR-3) agonist peptide.
DC42020	Protease-Activated Receptor-1, PAR-1 Agonist	Protease-Activated Receptor-1, PAR-1 Agonist is a thrombin-specific, protease-activated receptor 1 (PAR-1)-specific agonist peptide.