IC 86621|cas 404009-40-1|DC Chemicals

Cas No.:	404009-40-1
Chemical Name:	1-(2-hydroxy-4-morpholin-4-ylphenyl)ethanone
Synonyms:	HMS3229C13; CTK1D4579; IC86621; CHEMBL1317546; DNA-PK Inhibitor III; I2159_SIGMA; 1-(2-Hydroxy-4-morpholin-4-yl-phenyl)ethanone; AR2783; SureCN600210; 1-(2-hydroxy-4-morpholin-4-yl-phenyl)-ethanone;
SMILES:	CC(=O)C1=C(O)C=C(C=C1)N2CCOCC2
Formula:	C₁₂H₁₅NO₃
M.Wt:	221.2524
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

IC 86621 is a potent DNA-PK inhibitor with IC50 of 135 nM, also inhibits p110β (IC50=135 nM), less potent for p110α/γ/δ (IC50=880-1,400 nM); directly inhibits the repair of DNA DSBs and consequently enhances the cytotoxicity of physical and chemical agents that induce DSBs but not other DNA lesions.

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