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PDI inhibitor 16F16

  Cat. No.:  DC23762   Featured
Chemical Structure
922507-80-0
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More than 5000 active chemicals with high quality for research!
Field of application
PDI inhibitor 16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation.
Cas No.: 922507-80-0
Chemical Name: 1H-Pyrido[3,4-b]indole-1-carboxylic acid,2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-, methyl ester
Synonyms: 1H-Pyrido[3,4-b]indole-1-carboxylic acid,2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-, methyl ester;methyl 2-(2-chloroacetyl)-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indole-1-carboxylate
SMILES: ClCC(N1CCC2C3=CC=CC=C3NC=2C1(C)C(OC)=O)=O
Formula: C16H17ClN2O3
M.Wt: 320.770783185959
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A small molecule protein disulfide isomerase (PDI) inhibitor that suppress apoptosis induced by misfolded proteins; protects rat neurons from cell death triggered by Aβ peptide; reduces Zika virus replication in vitro but demonstrates notable toxicity; inhibits CHIKV E1-induced cell-cell fusion.
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